Spermidine in mice: a natural compound that slows aging?

Introduction

As we age, our cells gradually deteriorate. Researchers are looking for natural compounds that might slow this process. Spermidine, a substance found in many foods, has shown promise in animals by extending lifespan and reducing age-related diseases.

What the study did

This review looked at multiple animal studies on spermidine. The studies included fungi, worms, flies, and mice. Researchers measured lifespan and signs of age-related conditions like heart disease and brain decline. The goal was to understand how spermidine works at the cellular level.

What it found

• Spermidine extended the lifespan of fungi, worms, flies, and mice.
• In mice, it delayed the onset of age-related diseases such as cardiovascular disease and neurodegeneration.
• The compound appears to work by triggering a cellular cleanup process called autophagy.

How much to trust it

Trust tier: Early-stage · Animal-only. This is a review of animal studies, so results may not apply to humans. The biggest limitation is that all evidence comes from non-human organisms, and human trials are needed to confirm any benefits.

Your action plan

• Eat foods naturally rich in spermidine, such as wheat germ, soybeans, and aged cheese, as part of a balanced diet.
• Maintain a healthy lifestyle with regular exercise and sleep, which also support cellular health.
• Do not take spermidine supplements without professional guidance, as safe doses for humans are not established.

This summary is for general information only and is not medical advice. Talk to a qualified professional before changing anything about your health.

Source

Mechanisms of spermidine-induced autophagy and geroprotection.. Nature aging. 2022 PubMed